Buy Celebrex Online

Active Ingredient: Celecoxib
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About the preparation, composition, form of release

Celebrex is an anti-inflammatory agent of non-steroidal structure, which is produced by the pharmaceutical company Pfizer. It is widely used for the treatment of pain associated with inflammatory processes of the musculoskeletal system, and other acute and chronic pain.

The active ingredient of Celebrex is celecoxib. The drug is available in the form of white gelatin capsules of 100 mg, 200 mg and 400 mg. The capsules have 2 stripes of the corresponding colors – blue, yellow and green. One of the strips shows the dosage of the drug, and the other is marked "7767".

celecoxib celebrex

In addition to the main component, the capsules include milk sugar, sodium dodecyl sulfate, sodium croscarmellose, magnesium salt of stearic acid, gelatin, titanium dioxide, gelatin and polyvidone K30. The drug is available in cell blisters, the secondary packaging is a cardboard box.

The active component of Celebrex - Celecoxib - is a specific inhibitor of the enzyme cyclooxygenase-2 (COX-2) of the first generation.

Inhibition of this enzyme leads to a delay in the synthesis of prostaglandins - inflammatory mediators. In addition, prostaglandins increase the sensitivity of pain receptors to pain mediators and have a pyrogenic effect on the thermoregulation centers in the brain.

Thus, by stopping the formation of prostaglandins, an anti-inflammatory, analgesic and antipyretic effect is carried out. Celebrex practically does not slow down the work of COX-1, so taking the drug does not affect the production of "useful" prostaglandins, which are normally present in the intestines, stomach and platelets in all healthy people.

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What does the drug help from?

Almost any pathological changes in the body are accompanied by pain and inflammatory processes - Celebrex helps relieve pain and inflammation, therefore it is used for these symptoms in many areas of medicine.

The effect of the drug includes the removal of inflammation, redness, swelling, pain, itching and fever. Celecoxib has undergone many clinical studies, as a result of which the most sensitive diseases and conditions to the action of the drug have been identified:

  • Acute musculoskeletal pathologies (for example, shoulder periarthritis, subacromial bursitis, arthritis with gout);
  • Chronic musculoskeletal pain (e.g. ankylosing spondylosis, rheumatic pains);
  • Toothache;
  • Postoperative pain;
  • Menstrual pains;
  • Familial adenomatous polyposis;
  • Adenoma of the colon.

The classic area of application of Celebrex is the control of chronic and elimination of acute pain in diseases of the musculoskeletal system, after injuries and in the postoperative period. The use of this NSAID helps to reduce the dose of opioid medications taken.

In addition to the standard use of the drug, in clinical conditions they found out about the possible prospects of using Celebrex 200 for the treatment of patients with schizophrenia, since this substance has a positive effect on neurodegenerative processes.

Capsules are taken after meals, washed down with a glass of warm water. The medicine should not be chewed or divided into parts. The instructions for use of Celebrex 200 mg indicate that the standard recommended dosage for treatment is 200 mg of the drug per day.

  • The maximum dose is 800 mg - 4 capsules.
  • For rheumatoid arthritis, take 200-400 mg / 2 times a day.
  • With osteoarthritis - 100-200 mg of the drug per day.

Depending on the severity of the pain syndrome, to relieve acute pain, you can take 200-400 mg once and then, if necessary, take another 200 mg, but no more than twice a day.

Familial adenomatous polyposis requires the use of 400 mg of Celebrex twice a day. The drug should be prescribed in minimal therapeutic doses for a short period of time to prevent the development of side effects.

Side effects and contraindications

The use of Celebrex 200 mg capsules (sometimes they are mistakenly called tablets) cannot be combined with taking other NSAIDs. Due to the peculiarities of metabolism, complex use with warfarin can cause bleeding.

Prescribing the drug with ketoconazole and fluconazole increases the concentration of Celecoxib twice. Taking angiotensin-2 blockers reduces the antihypertensive effect of the latter.

Taking Celebrex with Lithium preparations requires constant monitoring, since the concentration of lithium increases by almost 20%. Treatment of persons of the black race should be carried out starting from the minimum dosages due to the presence of a specific metabolism in such patients.

The most common side effects with prolonged use of Celebrex are:

  • Pain in the epigastric region, diarrhea, vomiting, nausea, possible development of intestinal bleeding, etc.
  • Headache, drowsiness, dizziness, tinnitus, confusion;
  • Hypertension, arrhythmia, tachycardia, peripheral edema;
  • Respiratory infections;
  • Infections of the genitourinary system;
  • Thrombocytopenia, anemia;
  • Changes in AST and ALT activity;
  • Allergic reactions.

In rare cases, prolonged use of Celebrex is fraught with cardiotoxic effect and can cause myocardial infarction, as well as thrombosis in vital organs. The drug is contraindicated in pregnant women and women during lactation, as well as children under 18 years of age.

In addition, it is not recommended to take Celebrex with serious hepatic and renal pathologies, allergies to acetylsalicylic acid and ulcerative lesions of the gastrointestinal tract.

Heart failure and coronary artery bypass grafting are also contraindications to taking the drug.

In case of overdose, side effects may manifest more intensively, there is no specific treatment, supportive therapy is used to alleviate the condition.

celebrex tablets

Analogues of Celebrex are drugs containing celecoxib — they may vary in price, but the therapeutic effect remains the same.

Remember that a doctor's consultation is mandatory, but if you are going to use an analogue of an already prescribed Celebrex - instructions for use, the price and reviews of analogues do not apply and cannot be used as a guide for treatment. When replacing with an analog, you may need to adjust the dosage or treatment regimen, do not self-medicate!

Due to its active substance, Celebrex is one of the most popular and effective NSAIDs for the symptomatic treatment of the osteoarticular system and other pain syndromes. Its selective effect on COX-2 reduces the number of side effects and increases the breadth of therapeutic activity.